Stage- and tissue-specific effect of cyclophosphamide during tooth development

ConclusionDefective phenotypes were evident in both crown and roots due to the effect of CPA. Interestingly, the severity of the phenotypes was associated with the developmental stages of the tooth germs at the time of CPA administration. The cap/early bell stage is the most susceptive timing for tooth agenesis, whereas the late bell stage is predominantly affected in terms of root formation by CPA administration.
Source: The European Journal of Orthodontics - Category: Dentistry Source Type: research