Integrating radiomics into clinical trial design.

Integrating radiomics into clinical trial design. Q J Nucl Med Mol Imaging. 2019 Sep 13;: Authors: Waninger JJ, Green M, Cheze Le Rest C, Rosen B, El Naqa I Abstract In radiomics, quantitative features that describe phenotypic tumor characteristics are derived from radiographic images. Because radiomics generates information from routine medical images, it is a powerful way to non-invasively examine the spatial and temporal heterogeneity of disease, and thus has potential to significantly impact clinical trial design, execution, and ultimately patient care. The aim of this review article is to discuss how radiomics may address some of the current challenges in clinical randomized control trials, and the difficulties of integrating robust and repeatable radiomics analysis into trial design. Each step of the radiomics process, including image acquisition and reconstruction, image segmentation, feature extraction, and computational analysis, requires extensive standardization in order to be successfully incorporated into clinical trials and inform clinical decision making. By addressing these challenges, the potential of radiomics may be realized. PMID: 31527581 [PubMed - as supplied by publisher]
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

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This article reports segmental absence of tracheal cartilage rings in a kitten. An 8-month-old female kitten was presented with a history of weight loss and respiratory distress for 2 months. Radiographs of the thorax demonstrated a large air-filled sac suggestive of pneumomediastinum. No cartilaginous structures were evident radiographically over the caudal portion of the trachea. At necropsy examination, approximately 2 cm from the carina, a 3 cm segment of the trachea lacked cartilaginous rings. The clinical and morphological features of this lesion were similar to those described in human and canine cases of ...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
AbstractPurposeThe purposes of this study were to investigate the anatomical risk factors of grade 3  J-sign and analyse the influence of J-sign grades on the short-term clinical outcomes of patients with recurrent patellar dislocation.MethodsFrom 2016 to 2018, a total of 168 patients with recurrent patellar dislocation (187 knees) underwent medial patellofemoral ligament reconstruction with or without tibial tuberosity medialization. Pre-operative J-sign severity was graded according to a previously described classification (grades 1 –3). Potential anatomical risk factors of J-sign were explored. Comparisons we...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
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Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
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Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
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Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
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Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
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