Oxidant and Antioxidant Effects of Gentisic Acid in a 177Lu-Labelled Methionine-containing Minigastrin Analogue.

CONCLUSION: The selective oxidation of the methionine residue could be induced by the H2O2 produced in the reaction between gentisic acid and free radicals of water, during the protection of the radiolabelled peptide from the attack of these harmful species. Therefore, the addition of methionine becomes necessary to effectively decrease this selective oxidation in the methionine-containing peptide. PMID: 31526356 [PubMed - as supplied by publisher]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research