Allogeneic Microbiota-reconstitution (AMR) in Diarrhea-predominant Irritable Bowel Syndrome (IBS-D)

Condition:   Diarrhea-predominant Irritable Bowel Syndrome Interventions:   Procedure: Allogeneic microbiota reconstitution;   Procedure: Placebo-Allogeneic microbiota reconstitution Sponsors:   University of Ulm;   Klinikum Ludwigsburg;   Helios Klinikum Krefeld;   Charite University, Berlin, Germany;   Assign International, Berlin, Germany Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Authors: Masuy I, Pannemans J, Tack J Abstract Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders (FGIDs) encountered in clinical practice. In the absence of an accurate biomarker for the disorder, IBS is mainly diagnosed based symptomology using the Rome criteria. Due to the heterogeneity of the disorder, finding the correct treatment option is often challenging. In general, lifestyle and dietary changes, including the low-FODMAP of gluten-free diet, are the first-in-line treatment for all patients. Issues with dietary changes are the strict elimination of multiple food ...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Abstract Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with recurrent abdominal pain and altered defecation habits. We here attempted to determine the effect of acupuncture on IBS. Methods: Randomized controlled trials (RCTs) published in CNKI, VIP, Wanfang, PubMed, Cochrane Library, EMBASE, Web of science, and ClinicalTrials.gov till July 17, 2019 were searched. Outcomes were total efficacy rates, overall IBS symptom scores, or global quality of life scores. Standardized mean difference (SMD) with 95% confidence intervals (CI) and risk ratio (RR) with 95% CI were calcul...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Condition:   Irritable Bowel Syndrome Interventions:   Drug: Melatonin and standard therapy for IBS;   Other: Standard medical therapy and placebo Sponsor:   Sanjay Gandhi Postgraduate Institute of Medical Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, this study demonstrates that the Clostridia-rich microbiota contributes to excessive BA excretion in IBS-D patients, which provides a mechanistic hypothesis with testable clinical implications.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Excessive fecal bile acid (BA) loss causes symptoms in a large proportion of people diagnosed with irritable bowel syndrome with diarrhea, a common functional bowel disorder. This BA diarrhea (BAD) results from increased hepatic synthesis of BAs, with impaired negative feedback regulation by the ileal hormone fibroblast growth factor 19 (FGF19). In this issue of the JCI, Zhao et al. investigated BA metabolism, including fecal BAs, serum BAs, and FGF19, in patients and controls. They identified associations between fecal bacterial BA metabolism and specific microbiota, especially Clostridium scindens. These findings have be...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionsMindfulness is associated with low symptom interference, high self-compassion, and low distress in IBS. The observed association between mindfulness and low distress is partly related to high self-compassion and low symptom interference. The observed association between symptom frequency and interference is not as strong among those reporting high levels of mindfulness. Overall, this study strengthens justification for the use of MBIs in IBS.
Source: Mindfulness - Category: Psychiatry & Psychology Source Type: research
Dana Carpender, friend and author of many low-carb cookbooks, provided this review of my new Revised &Expanded Wheat Belly, below. For more of Dana’s signature wit and conversation, you can join her on her engaging Facebook page “Hold the toast press” or visit her Amazon page that lists all her wonderful low-carb cookbooks. It’s funny how things happen. Nine years ago I had already been eating a low carbohydrate diet for 16 years. During that time I had occasionally eaten low carb tortillas and low carb bread. These things were hardly a staple of my diet, but I kept ’em around for the occ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open autoimmune joint pain wheat belly Source Type: blogs
Background: Irritable bowel syndrome (IBS) is a stress-sensitive disorder of brain-gut interactions associated with a higher prevalence of early adverse life events (EALs). However, it is incompletely understood how trauma severity or disclosure influence the risk of developing IBS or symptom severity. Aims: To determine whether (1) IBS patients report a greater number of EALs compared with healthy controls; (2) trauma severity and first age of EAL increase the odds of IBS; (3) confiding in others reduces the odds of IBS; (4) the number, trauma severity, and first age of EAL are associated with symptom severity; (5) s...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
Conclusions: The correlations between the behavioral patterns and biochemical oxidative stress features could suggest that this may be a complex model, which can successfully mimic IBS symptomatology further providing evidence of a strong connection between the digestive system, enteric nervous system, and the central nervous system. PMID: 31817740 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
AbstractWith an avid attention to the valuing of embodiment and a championing of the re-emergence of the body as site for discussions of knowledge and knowing, this essay shares aspects of my practice that engage a performative, haptic, situated engagement with the body through the artist ’s book. The motivation for the creation of my bookworks was an interest in manifesting situated knowing and embodied ways of becoming. Engaging form, materiality, and bodily history, my artists’ books explore the processes and metaphors of digestion and in one example, mindfulness practice. In libraries and collections with l...
Source: Journal of Medical Humanities - Category: Medical Ethics Source Type: research
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