Verteporfin inhibits fibrosis, inflammation and angiogenesis related genes in uterine fibroid cells
Uterine fibroids are characterized by abnormal cell proliferation and apoptosis, leading to excessive growth and secretion of an altered extracellular matrix (ECM). A key signaling pathway controlling cell proliferation and apoptosis is the Salvador/Warts/Hippo pathway. Hippo signaling is mediated by the TEA domain family member (TEAD)/Yes-associated protein (YAP)/(transcriptional co-activator with PDZ-binding motif (TAZ) transcription factors. Verteporfin, a benzoporphyrin derivative, is known to inhibit the interaction between TEAD and YAP/TAZ.
ConclusionThe vast majority of included RCTs had a low level of evidence, thereby preventing the establishment of a hierarchy of treatments. Nevertheless, our results provide an overview of the main AGW treatments available for general practitioners and specialists. While provider-administered treatments are superior, patient-administered treatments (e.g., imiquimod, podophyllotoxin) are useful solutions for compliant patients.Protocol registrationPROSPERO-CRD42015025827.
Conclusion: Oral isotretinoin is superior to placebo for treating mucocutaneous human papillomavirus infections, particularly plane warts. The recurrence rate and risk of severe side effects are low.
Conclusions: In conclusion, we report five patients who developed skin warts during fingolimod therapy, especially HPV-related, for an overall incidence of 2.2%. Larger cohorts are needed to confirm this proposed higher susceptibility of fingolimod-treated patients to HPV infections.
This study estimated genital warts prevalence, genital-warts-related healthcare resource use and costs, and self-reported human-papillomavirus-related psychosocial impact among male and female patients aged 18...
ConclusionNZCS was an effective treatment of warts in this pediatric population. The painlessness, simplicity, and twice-monthly dosing regimen of this treatment represents an advantage over standard approaches.FundingISDIN.Trial RegistrationRetrospectively registered 6 September 2019, ISRCTN90862249.
(Natural News) Acupuncture is a traditional form of medicine used by the ancient Chinese to relieve pain and other ailments. Today, it is commonly associated with the use of needles that target certain points or meridians spread throughout the body. Over the years, research have produced sufficient evidence to support the effectiveness of acupuncture in treating a number of conditions, such...
CONCLUSION: This study enforced an analysis of research trends on gynecologic malignancies in North Korean and South Korea medical journals, and a distinct difference was observed in this regard. In the future, grand scale cohort study in the genetic identical two Korean population is needed for research of environmental effect on gynecologic cancer. PMID: 31554378 [PubMed - in process]
Two new species (Melanoleuca galerina and M. subgrammopodia) and seven new recorded species from northern China are described here using morphological and molecular methods. Melanoleuca galerina is mainly characterized by its hygrophanous pileus, decurrent lamellae, fibrous stipe and spores with round warts. Key characteristics of M. subgrammopodia include its discolored pileus, fibrous stipe and urticiform cystidia. The divergence time of Melanoleuca fungi as well as the phylogenetic relationships within this genus were analyzed using DNA sequences of the internal transcribed spacer (ITS) and the nuclear large subunit rDN...
Abstract Warts are benign neoplasms of the skin and mucosa caused by human papillomavirus (HPV) infection.1 The most common treatments for wart are topical application of salicylic acid and cryotherapy. Other modalities include chemical agents, contact sensitizing agents and surgical excision.2 Laser modalities, including carbon dioxide (CO2 ), pulsed dye and neodymium-doped: yttrium-aluminum-garnet lasers, have also been used to treat recalcitrant plantar warts. PMID: 31545511 [PubMed - as supplied by publisher]
Focuses on the prevention of 5 common sexually transmitted infections (STIs) - gonorrhoea, chlamydia, syphilis, genital herpes and genital warts. It also covers the public health challenge of antimicrobial-resistant STIs and the commissioning and improvement of sexual health services.