Verteporfin inhibits fibrosis, inflammation and angiogenesis related genes in uterine fibroid cells

Uterine fibroids are characterized by abnormal cell proliferation and apoptosis, leading to excessive growth and secretion of an altered extracellular matrix (ECM). A key signaling pathway controlling cell proliferation and apoptosis is the Salvador/Warts/Hippo pathway. Hippo signaling is mediated by the TEA domain family member (TEAD)/Yes-associated protein (YAP)/(transcriptional co-activator with PDZ-binding motif (TAZ) transcription factors. Verteporfin, a benzoporphyrin derivative, is known to inhibit the interaction between TEAD and YAP/TAZ.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research