RelB regulates lymphatic endothelial cells during vessel maturation and is required for lymphatic vessel function in adult mice

NF- κB signals through canonical RelA/p50 and noncanonical RelB/p52 pathways. The RelA/p50 is involved in basal and inflammatory lymphangiogenesis. However, the role of RelB/p52 in lymphatic vessel biology is unknown. Here, we investigated changes in lymphatic vessels (LVs) in mice deficient in noncano nical NF-κB signaling, and the function of RelB in lymphatic endothelial cells (LECs). LVs were examined in Relb-/-, p52-/-, or control mice, and the gene expression profiles in LECs with RelB knockdown.

Source: American Journal of Pathology - September 16, 2019 Category: Pathology Authors: Qianqian Liang, Li Zhang, Ronald W. Wood, Rui-Cheng Ji, Brendan F. Boyce, Edward.M. Schwarz, Yongjun Wang, Lianping Xing Tags: Regular Article Source Type: research