Chondrocalcinosis: idiopathic or manifestation of rare metabolic diseases?

[Chondrocalcinosis: idiopathic or manifestation of rare metabolic diseases?] Orthopade. 2019 Sep 12;: Authors: Knitza J, Kleyer A, Schett G, Manger B Abstract Calcification in hyaline and fibrocartilage is caused by the deposition of calcium pyrophosphate dehydrate, commonly referred to as chondrocalcinosis. Clinically, this can lead to arthritis symptoms similar to a gout attack -"pseudogout". Nonetheless, also chronic or asymptomatic disease courses are possible. The prevalence of chondrocalcinosis increases with age. The diagnostic workup of degenerative joint disease, therefore, often reveals calcifications of articular cartilage as harmless incidental findings. However, particularly in patients younger than 60 years of age, chondrocalcinosis can be the symptom of an underlying metabolic disease. This review article highlights these rare diseases and presents unusual manifestations of chondrocalcinosis. PMID: 31515589 [PubMed - as supplied by publisher]
Source: Der Orthopade - Category: Orthopaedics Authors: Tags: Orthopade Source Type: research

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Abstract Polymorphisms in the LPA gene have been associated with aortic valve calcification (AVC). There are wide differences in the allelic frequencies, Lp(a) levels, and the association with AVC among ethnic groups. The aim of this study was to determine the association of the LPA gene polymorphisms with Lp(a) levels and risk of developing AVC, in Mexican-Mestizos population. Six LPA polymorphisms (rs10455872, rs7765803, rs6907156, rs1321195, rs12212807 and rs6919346) were genotyped by TaqMan assays in 1,265 individuals without premature coronary artery disease. The presence of AVC was determined by computed tomography. ...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
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Source: European Journal of Radiology - Category: Radiology Source Type: research
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Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: Research and Development Rare Diseases Pelosi Plan Source Type: news
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Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
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Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
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Source: - Category: Research Source Type: clinical trials
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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