Keratin defects trigger the itch-inducing cytokine thymic stromal lymphopoietin through amphiregulin –epidermal growth factor receptor signaling
Chronic inflammatory skin diseases, such as atopic dermatitis, result from an overactive immune response in combination with epidermal barrier defects. The subsequent intrusion of allergens or pathogens stimulates keratinocytes to produce antimicrobial peptides, cytokines, and chemokines to restore epidermal homeostasis. One of these cytokines is thymic stromal lymphopoietin (TSLP), which plays a crucial role in TH2 immune responses by triggering dendritic cell activation and CD4+ T-cell differentiation.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Andrea Scheffschick, Dimitra Kiritsi, Thomas M. Magin Tags: Letter to the Editor Source Type: research