A New Model for Standardising and Treating Thermal Injury in the Rat

We describe a rat thermal burn model that involves: anaesthesia, chronic catheterisation, skin preparation, baseline hemodynamic and physiological monitoring, and a quantifiable method to reproduce a severe full-thickness burns injury affecting ∼30% percent of the total body surface area (%TBSA). Following a 15 min post-burn period, treatment commences with an acute monitoring phase lasting up to 8 hours, which can be modified according to individual protocols. This model reflects the clinical continuum-of-care from point-of injury, a 15 min ambulance response time, a 60 min prehospital phase and hospital treatment monitoring phase. The model is validated with histological evidence of full-thickness injury, evidence of the hypermetabolic response (K+, Base Excess, lactate) and changes in complete blood counts.•It has been 50 years since Walker and Mason published their widely popular a standard animal burn model.•The model, however, lacks quantifiable methodology for the assessment of burn thickness, surface area burnt and physiological status.•We present a new standardised method for evaluation of drug and interventional therapies that mimic the clinical scenario including ambulance response, pre-hospital and hospital phases after burn.Graphical abstract
Source: MethodsX - Category: Science Source Type: research

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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Breast Cancer health Source Type: news
Abstract Severe burn injury results in systemic disruption of metabolic regulations and impaired cardiac function. Restoration of hemodynamic homeostasis utilizing intravenous (IV) fluids is critical for acute care of the burn victim. However, the effects of burns and resuscitation on cardiomyocyte mitochondria arecurrently unknown. The purpose of this study is to determine cardiac mitochondrial function in a swine burn model with subsequent resuscitation using either crystalloids or colloids. Anesthetized Yorkshire swine (n=23) sustained 40% total body surface area (TBSA) burns and received IV crystalloids (n=11)...
Source: Am J Physiol Cell Ph... - Category: Cytology Authors: Tags: Am J Physiol Cell Physiol Source Type: research
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Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Kapil D Soni, Thanigai Arasu, Richa Aggarwal, Vanlal DarlongJournal of Anaesthesiology Clinical Pharmacology 2019 35(3):412-413
Source: Journal of Anaesthesiology Clinical Pharmacology - Category: Anesthesiology Authors: Source Type: research
We present a rare case of an 18-month-old boy with Dandy–Walker syndrome presenting with 17% total body surface area burns undergoing multiple general anesthetics for both operative and bedside procedures. Numerous lessons were learned during multiple anesthetics, which influenced and guided our subsequent anesthetic management. The preoperative assessment, risk for respiratory apnea, opioid management, risk for laryngospasm, and postoperative care of patients with Dandy–Walker syndrome were all lessons learned.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports Source Type: research
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Source: Burns - Category: Dermatology Source Type: research
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Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
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Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
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Source: Anesthesiology - Category: Anesthesiology Source Type: research
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