Adhesive mechanism of different Salmonella fimbrial adhesins

Publication date: Available online 12 September 2019Source: Microbial PathogenesisAuthor(s): Tayyab Rehman, Lizi Yin, Muhammad Bilal LATIF, Jiehao Chen, Kaiyu Wang, Yi Geng, Xiaoli Huang, Muhammad Abaidullah, Hongrui Guo, Ping OuyangAbstractSalmonellosis is a serious threat to human and animal health. Salmonella adhesion to the host cell is an initial and most crucial step in the pathogenesis of salmonellosis. Many factors are involved in the adhesion process of Salmonella infection. Fimbriae are one of the most important factors in the adhesion of Salmonella. The Salmonella fimbriae are assembled in three types of assembly pathways: chaperon–usher, nucleation–precipitation, and type IV fimbriae. These assembly pathways lead to multiple types of fimbriae. Salmonella fimbriae bind to host cell receptors to initiate adhesion. So far, many receptors have been identified, such as Toll-like receptors. However, several receptors that may be involved in the adhesive mechanism of Salmonella fimbriae are still un-identified. This review aimed to summarize the types of Salmonella fimbriae produced by different assembly pathways and their role in adhesion. It also enlisted previously discovered receptors involved in adhesion. This review might help readers to develop a comprehensive understanding of Salmonella fimbriae, their role in adhesion, and recently developed strategies to counter Salmonella infection.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research

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Publication date: December 2019Source: Microbial Pathogenesis, Volume 137Author(s): Junlei Yin, Zhao Cheng, Yuchen Wu, Qunli He, Jingjing Zhang, Zhanfeng Yang, Shuming Ding, Jizong Li, Dongguang GuoAbstractParatyphoid fever caused by Salmonella Paratyphi A is a serious public health problem in many countries. In order to and develop a live attenuated candidate vaccine of Salmonella Paratyphi A, a Salmonella pathogenicity island 2 (SPI2, approximate 40 kb) deletion mutant of Salmonella Paratyphi A was constructed by lambda Red recombination, then the biological characteristics and protective ability of the Salmonella Para...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Foodborne Pathogens and Disease - Category: Food Science Authors: Source Type: research
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Source: Gut Pathogens - Category: Microbiology Source Type: research
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Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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