Electrically evoked compound action potential artifact rejection by independent component analysis: Technique validation.

Electrically evoked compound action potential artifact rejection by independent component analysis: Technique validation.
Hear Res. 2013 Apr 28;
Authors: Akhoun I, McKay CM, El-Deredy W
Abstract
The electrically-evoked compound action potential (ECAP) is the synchronous whole auditory nerve activity in response to an electrical stimulus, and can be recorded in situ on cochlear implant (CI) electrodes. A novel procedure (ECAP-ICA) to isolate the ECAP from the stimulation artifact, based on independent component analysis (ICA), is described here. ECAPs with artifact (raw-ECAPs) were sequentially recorded for the same stimulus on 9 different intracochlear recording electrodes. The raw-ECAPs were fed to ICA, which separated them into independent sources. Restricting the ICA projection to 4 independent components did not induce under-fitting and was found to explain most of the raw-data variance. The sources were identified and only the source corresponding to the neural response was retained for artifact-free ECAP reconstruction. The validity of the ECAP-ICA procedure was supported as follows: N1 and P1 peaks occurred at usual latencies; and ECAP-ICA and artifact amplitude-growth functions (AGFs) had different slopes. Concatenation of raw-ECAPs from multiple stimulus currents, including some below the ECAP-ICA threshold, improved the source separation process. The main advantage of ECAP-ICA is that use of maskers or alternating polarity stimulatio...

Source: Hearing Research - April 28, 2013 Category: Audiology Authors: Akhoun I, McKay CM, El-Deredy W Tags: Hear Res Source Type: research