scBFA: modeling detection patterns to mitigate technical noise in large-scale single-cell genomics data

Technical variation in feature measurements, such as gene expression and locus accessibility, is a key challenge of large-scale single-cell genomic datasets. We show that this technical variation in both scRNA...

Source: Genome Biology - September 9, 2019 Category: Genetics & Stem Cells Authors: Ruoxin Li and Gerald Quon Tags: Method Source Type: research