Prospective evaluation of micropulse transscleral diode cyclophotocoagulation in refractory glaucoma: 1 year results

Conclusions: Micropulse transscleral diode cyclophotocoagula tion was safe and effective for reducing intraocular pressure in eyes with refractory and advanced glaucoma, with reduced need for ocular antihypertensive medication.RESUMO Objetivo: Avaliar a efic ácia na redução da pressão intraocular e na segurança da ciclofotocoagulação com laser de diodo transescleral em glaucoma refratário. Métodos: Avaliamos prospectivamente uma série de casos de 21 olhos de 21 pacientes com glaucoma refratário tratados com ciclofotocoagulação com laser de diodo transescleral com acompanhamento por 12 meses. O tempo total de tratamento ficou a critério do cirurgião, considerando a pressão intraocular inicial e alvo e o tipo de glaucoma. Pressão intraocular, inflamação, acuidade visual e número de medicamentos foram monitorados. O sucesso foi d efinido como pressão intraocular entre 6 e 21 mmHg e/ou redução de 30% da pressão intraocular basal com ou sem o uso de medicamentos glaucomatosos. Perda da acuidade visual foi definida como perda de ≥ 2 linhas de vis ão na tabela de Snellen ou uma diminuição de ≥ 2 n íveis na função visual em pacientes com acuidade do gráfico não mensurável. Resultados: A idade média foi de 61,04 ± 12,99 anos e 11 (52,4%) ...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research

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This study reports a significant increase in the levels of autotaxin, lysophosphatidylcholine (LPC), LPA and connective tissue growth factor (CTGF) in the AH of Caucasian and African American open angle glaucoma patients relative to age-matched non-glaucoma patients. Treatment of human TM cells with dexamethasone, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) increased the levels of autotaxin protein, a response that was mitigated by inhibitors of glucocorticoid receptor, NF-kB and SMAD3. Dexamethasone, TNF-α, IL-1β and LPC treatment of TM cells also led to an increase in the l...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Meihao Sun Glaucoma is considered a leading cause of blindness with the human eye being one of the body’s most delicate organs. Ocular diseases encompass diverse diseases affecting the anterior and posterior ocular sections, respectively. The human eye’s peculiar and exclusive anatomy and physiology continue to pose a significant obstacle to researchers and pharmacologists in the provision of efficient drug delivery. Though several traditional invasive and noninvasive eye therapies exist, including implants, eye drops, and injections, there are still significant complications that arise which may e...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Conclusion: Stereoacuity decreases with increasing grades of cataract. Better stereoacuity is seen in patients with bilateral pseudophakia when compared with high grades of cataract.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Conclusion: RNFL had better diagnostic ability, when compared with GCL-IPL for detecting PPG and perimetric glaucoma. However, difference was small and may not be clinically relevant.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
We report the surgical technique of a new modified fornix-based separate-site phacotrabeculectomy, with mitomycin C (MMC) application, in both primary open angle and angle closure glaucoma. In this new separate-site technique, both phaco and filtration are accommodated superiorly, side by side, hence called twin-site. This was achieved in an efficacious and safe manner with sparing of limbal stem cells without compromising safety. It is not only MMC-compatible but also has a low incidence of wound leak. The technique has no adverse consequence on the survival of the bleb, and we achieved complete success in 79.2% and t...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Preetkanwar Singh Sodhi, Neelima Sodhi, Jaswinderpal Singh SodhiIndian Journal of Ophthalmology 2019 67(11):1907-1908
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Charudutt Kalamkar, Amrita MukherjeeIndian Journal of Ophthalmology 2019 67(11):1908-1908
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Conditions:   Open-Angle Glaucoma or Ocular Hypertension;   Ocular Surface Disease Interventions:   Drug: DE-130A;   Drug: Xalatan® Sponsor:   Santen SAS Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Volume 29, Issue 10, October 2019, Page 745-747 .
Source: Expert Opinion on Therapeutic Patents - Category: Drugs & Pharmacology Authors: Source Type: research
Periventricular leukomalacia (PVL) is a structural loss of white matter pathways that carry visual information from the lateral geniculate bodies to the visual cortex. It is observed radiologically in patients with a history of prematurity and is associated with visual field defects and optic disc cupping. Advances in perinatal care have improved survival for premature babies, so many now present as adolescents and adults to comprehensive eye doctors who are unaware of the relationship of cupping, field defects, and prematurity and who may diagnose manifest or suspected normal tension glaucoma.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
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