Non-Degenerate Graphical Representation of Dna Sequences and its Applications to Phylogenetic Analysis.

Non-Degenerate Graphical Representation of Dna Sequences and its Applications to Phylogenetic Analysis.
Comb Chem High Throughput Screen. 2013 Apr 19;
Authors: Yang Y, Zhang Y, Jia M, Li C, Meng L
Abstract
In this paper, we propose a new 3-D graphical representation of a DNA sequence and prove that it has two well properties: (1) there is no circuit in the graph; (2) there exists an one-to-one correspondence between a DNA sequence and the graph. These properties guarantee it has nondegeneracy. Based on the 3-D graphical representation, we characterize a DNA sequence by a 12-dimensional vector whose components are normalized ALE-indexes of the corresponding L/L matrices. The proposed approach is tested by the phylogenetic analysis on three datasets, and the experimental assessment demonstrates its efficiency.
PMID: 23617263 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - April 19, 2013 Category: Chemistry Authors: Yang Y, Zhang Y, Jia M, Li C, Meng L Tags: Comb Chem High Throughput Screen Source Type: research