Caveolin-1 in Skin Aging From Innocent Bystander to Major Contributor.

Caveolin-1 in Skin Aging From Innocent Bystander to Major Contributor.
Ageing Res Rev. 2019 Sep 04;:100959
Authors: Kruglikov IL, Zhang Z, Scherer PE
Abstract
Caveolin-1 (Cav-1) appears to be both a pathophysiological contributor and a target in different inflammatory and hyperproliferative skin conditions as well as in skin aging. Skin fibroblasts demonstrate an up-regulation of Cav-1 expression both in chronological and UV-induced aging, and such an up-regulation was observed both in vitro and in vivo. Typical alterations in aging skin involve a reduction of the dermis thickness, a significant expansion of the dermal white adipose tissue as well as modifications of the content and distribution of hyaluronan, impairment of autophagic flux, a reduction of collagen expression and an increase in tissue inflammation. All of these phenomena can be connected with changes in Cav-1 expression in the aging skin. Modified expression of Cav-1 can also significantly influence the mechanical properties of individual skin layers, thus changing the total mechanical stability of the layered composite skin/WAT, leading to typical structural modifications of the skin surface in the aging skin. Selective reduction of Cav-1 expression has the potential to exert anti-aging effects on the skin.
PMID: 31493519 [PubMed - as supplied by publisher]

Source: Ageing Research Reviews - September 3, 2019 Category: Genetics & Stem Cells Authors: Kruglikov IL, Zhang Z, Scherer PE Tags: Ageing Res Rev Source Type: research