083 More Expression of IL-17 than IFN- γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion

Alopecia areata (AA) is an organ-specific autoimmune disease resulting from the attack of hair follicle (HF) autoantigens through T-cell-mediated mechanism. Beyond the hypothesis of immune privilege collapse, we suppose any change of memory regulatory T cells (mTregs) affect the balance between effector T cell subsets in AA pathogenesis. CD49a expression defines different functional subsets in Trm cells, for examples, CD8+ CD49a+ Trm cells produce IFN- γ in vitiligo lesions, whereas CD8+CD49a- Trm cells produce IL-17 in psoriatic lesions.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive Immunity and Autoimmunity Source Type: research