117 Combined therapeutic strategies for keloid treatment

Recent advances in keloid management favor the administration of combination therapy over monotherapy. We evaluated the safety and efficacy of combination therapy to treat keloids using fractional lasers, superficial cryotherapy, and intralesional triamcinolone injections. We performed a retrospective observational study involving 35 Koreans with keloids. Each patient underwent treatment using the 1550 nm non-ablative fractional erbium-glass laser, followed by the 10,600 nm ablative fractional carbon dioxide laser.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research

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Hypertrophic scarring and keloid can cause significant emotional and physical discomfort. Cosmetic appearance, functional limitations, pain and pruritus form a degree of impairment. While the aetiology is not fully known, there is a wide array of treatment options which include excision, radiation, cryotherapy, silicone gel sheeting and intralesional injections. A relatively new modality is laser therapy. While results are promising, the number of different laser systems is substantial. This review evaluates the available evidence regarding outcomes on specific objective characteristics (i.e., erythema, pigmentation, heigh...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
AbstractCommonly affecting those with skin of color, keloids are an aberrant wound response that leads to wound tissue expanding above and beyond the original cutaneous injury. Keloids are notoriously and particularly difficult to treat because of their tendency to recur after excision. The current standard of care is intralesional steroid (triamcinolone acetonide). However, because no therapy has yet proven to be fully curative, keloid treatments have expanded to include a number of options, from injections to multimodal approaches. This review details current treatment of keloids with injections (bleomycin, verapamil, hy...
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
Injury to skin triggers natural wound healing responses that may lead to scar formation, or excessive deposition of the extracellular matrix, mostly containing collagen [1]. With technological advances, many minimally or non-invasive means of treating scars have been used and are fairly effective, although results may be modest in keloids or hypertrophic scars [2]. Topical or injectable agents (i.e. steroids, interferon, 5-fluorouracil, plasma), passive microneedling, radiofrequency (RF) microneedling, fractional and non-ablative laser technology, radiation, high intensity focused ultrasound (HIFU), and cryotherapy have al...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
Authors: Sun P, Hu Z, Pan B, Lu X Abstract Keloid is a common and frequently-occurring disease in plastic surgery, and its ugly appearance and itching symptoms bring mental and life pain to patients. However, the clinical treatment of keloid, such as drug injection treatment, surgical resection, cryotherapy, laser treatment and other therapeutic effects are poor. Since the discovery of tumor necrosis factor related apoptosis inducing ligand (TRAIL) in 1995, its selective apoptosis on tumor cells makes it have a great prospect in the targeted treatment of tumor. In recent years, it has been found that the formation ...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
We report the case of a patient who suffered from major keloids on the scalp. After multiple sessions of intralesional cryotherapy, a complete eradication of the keloids was achieved.Level of Evidence: Level V, therapeutic study.
Source: European Journal of Plastic Surgery - Category: Cosmetic Surgery Source Type: research
CONCLUSION Combination keloid therapy using fractional lasers, superficial cryotherapy, and intralesional triamcinolone injection is safe and more effective than individual monotherapies.
Source: Dermatologic Surgery - Category: Dermatology Tags: Original Article Source Type: research
Autologous fat grafting is a technique with various applications in the craniofacial region ranging from the treatment of wounds, scars, keloids, and soft tissue deformities. In this review, alternative therapies to fat grafting are discussed. These are composed of established therapies like silicone gel or sheeting, corticosteroids, cryotherapy, and laser therapy. Novel applications of negative pressure wound therapy, botulinum toxin A injection, and biologic agents are also reviewed.
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Special Editorials Source Type: research
Cutaneous injury can ignite excessive fibroproliferative growth that results in keloid formation. Keloids are associated with significant morbidity related to disfigurement and/or symptoms (e.g. pain, pruritus). First ‐line treatment of formed keloids involves topical or intralesional steroids. Recurrent or resistant keloids are managed by surgical excision or cryotherapy, followed by steroidal application or adjuvant irradiation. While adjuvant irradiation appears to be most efficacious, alternative therapeuti c options are needed for patients without access to radiation centers. Botulinum Toxin A (BTA) appears to have ...
Source: Dermatologic Therapy - Category: Dermatology Authors: Tags: ORIGINAL PAPER Source Type: research
CONCLUSIONS: Patient-reported outcomes provide valuable insights into the perceptions, treatment goals, and quality of life of keloid patients. Development of more patient-reported outcome measures specific to keloids, especially those that incorporate both scar and quality of life assessments, may help refine our current understanding of keloid management. PMID: 30375208 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Publication date: December 2015Source: Journal of the American College of Clinical Wound Specialists, Volume 7, Issues 1–3Author(s): Walid Mari, Sami G. Alsabri, Najib Tabal, Sara Younes, Abdulamagid Sherif, Richard SimmanAbstractKeloid scar, dermal benign fibro-proliferative growth that extends outside the original wound and invades adjacent dermal tissue due to extensive production of extracellular matrix, especially collagen, which caused by over expression of cytokines and growth factors. Although many attempts were made to understand the exact pathophysiology and the molecular abnormalities, the pathogenesis of ...
Source: Journal of the American College of Clinical Wound Specialists - Category: General Medicine Source Type: research
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