392 Ruxolitinib cream ameliorates spontaneous atopic dermatitis in the IL-33 transgenic mouse model

Atopic dermatitis (AD) is characterized by intense itch and recurrent eczematous lesions. Interleukin (IL)-33 is constitutively produced from the structural and lining cells, including skin epithelial cells, which are exposed to the environment. Extracellular IL-33 binds to ST2 on T helper 2 (Th2) cells and various innate immune cells including mast cells, eosinophils and innate lymphoid cells. In AD patients, IL-33 overexpression in the epidermis, infiltration of ST2-positive cells and elevated serum IL-33 levels has been implicated in disease pathogenesis.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: M. Parker, B. Fay, W. Yao, P. Smith Tags: Innate Immunity and Inflammation Source Type: research