Upstate shines light on bladder cancer

Blue Light Cystoscopy helps doctors better detect and diagnose cancerous tumors in the bladder.
Source: SUNY Upstate Medical - Category: Universities & Medical Training Source Type: news

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To examine whether Photodynamic diagnosis (PDD) in addition to flexible cystoscopy in the outpatient clinic can reduce risk of tumour recurrence in patients with previous non-muscle invasive bladder cancer (NMIBC). PDD is an optical technique that enhances the visibility of pathological tissue and helps guidance tumour resection.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01911A, PaperFabian Placzek, Eliana Cordero, Simon Michael Kretschmer, Lara Wurster, Florian Knorr, Gerardo Gonzales-Cerdas, Mikael T. Erkkilae, Patrick Stein, Caglar Ataman, Gregers Hermann, Karin Mogensen, Thomas Hasselager, Peter E. Andersen, Hans Zappe, J ürgen Popp, Wolfgang Drexler, Rainer Leitgeb, Iwan W. Schie Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white... The content of this RSS...
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Conditions:   Cystoscope;   Bladder Cancer;   Lower Urinary Tract Symptoms Intervention:   Device: Ambu aScope 4 Cysto and aView Urologia Sponsors:   Ambu A/S;   QserveCRO Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Lopez-Beltran A, Cheng L, Gevaert T, Blanca A, Cimadamore A, Santoni M, Massari F, Scarpelli M, Raspollini MR, Montironi R Abstract Introduction: Bladder cancer detection typically requires unpleasant and costly cystoscopy, a procedure potentially harmful and often accompanied by variable adverse effects. The use of urine analysis as a non-invasive method is of great scientific interest since it is enriched in tumor-related proteins, DNA and RNA which can provide a molecular landscape with multiple alterations identified in bladder cancer.Areas covered: Current sensitivity, specificity and diagnostic accur...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
ConclusionsShe needed radical resection according to the actual situation. However, her age restricted her tolerance to general anesthesia; relatively conservative treatment options are available to ensure a high quality of life. The treatment of primary tumor resection combined with bladder perfusion chemotherapy is feasible. This case highlights the importance of the dissemination of new cases and optimizing primary urethral cancer diagnosis to obtain an effective treatment.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
AbstractPurpose of ReviewLocal tumor staging is paramount in the evaluation and management of bladder cancer. While neoadjuvant chemotherapy (NAC) followed by radical cystectomy and urinary diversion remains the gold standard for management of muscle-invasive bladder cancer, bladder-sparing regimens involving systemic chemotherapy and pelvic radiotherapy remain a viable option for select patients. Moreover, pre-cystectomy identification of patients with a complete response to NAC may obviate the need for radical cystectomy, but accurate post-therapy staging can be difficult to achieve. Contemporary imaging techniques may p...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
Abstract Initial clinical and pathological diagnostic workup of urinary bladder cancer is based on cystoscopy, transurethral resection of suspicious lesions, and computed tomography when indicated. Accurate staging is necessary for further therapeutic decision-making. This review summarizes the current status of multiparametric magnetic resonance imaging (mpMRI) and the vesical imaging-reporting and data system (VI-RADS) classification. MpMRI may improve the accuracy of assessment of local tumor invasion compared to conventional imaging alone. VI-RADS standardizes reporting of MRI staging and classifies the likeli...
Source: Nuklearmedizin - Category: Radiology Authors: Tags: Urologe A Source Type: research
Abstract PURPOSE: The evaluation of the potential clinical benefit of four-dimensional ultrasound (4D-US) in the assessment of bladder cancer (BC). MATERIAL AND METHODS: 20 patients with indication for cystoscopy for suspicion of bladder cancer were prospectively included in this study. All patients underwent two-dimensional ultrasound (2D-US), contrast enhanced ultrasound (CEUS) and real-time four-dimensional ultrasound (4D-US). All acquisitions were compared to each other in regard to image quality. This assessment was done using a 6 point scale (1 = best). All patients underwent subsequently cystoscopy...
Source: Clinical Hemorheology and Microcirculation - Category: Hematology Authors: Tags: Clin Hemorheol Microcirc Source Type: research
AbstractPurposeTo investigate the clinical performance of a new mRNA-based urine test, aiming to avoid unnecessary follow-up cystoscopy in patients under active surveillance (AS) for recurrent NMIBC.MethodsThis is a prospective cohort study enrolling patients with history of low-grade (LG) NMIBC, who developed a recurrence during the follow-up and underwent AS. Their urinary samples were analyzed by Xpert BC Monitor (Cepheid, Sunnyvale, CA, USA). The primary endpoint was to investigate if Xpert BC Monitor could avoid unnecessary cystoscopy during the follow-up period. Its sensitivity, specificity, PPVs and NPVs were calcul...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: As single-dose perioperative agents, both thiotepa and MMC were associated with similar recurrence-free survival rates. PMID: 31629441 [PubMed - in process]
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
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