The role of haemostasis in placenta-mediated complications
Normal pregnancy is associated with an increasing state of activation of the haemostatic system. This activation state is excessive in women with placenta-mediated pregnancy complications (PMPCs), including preeclampsia (PE). Platelet activation plays a crucial pathophysiological role in PE. The very early activation of coagulation in the intervillous space is mandatory for placental growth and morphogenesis but its excesses and/or inadequate control may participate to the emergence of the trophoblastic phenotype of PE.
Source: Thrombosis Research - Category: Hematology Authors: Jean-Christophe Gris, Sylvie Bouvier, Éva Cochery-Nouvellon, Éric Mercier, Ève Mousty, Antonia Pérez-Martin Tags: Full-length Article Source Type: research