niacin and lovastatin, Advicor

Title: niacin and lovastatin, AdvicorCategory: MedicationsCreated: 10/13/2004 12:00:00 AMLast Editorial Review: 8/29/2019 12:00:00 AM
Source: MedicineNet Cholesterol General - Category: Cardiology Source Type: news

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PCSK9 inhibitor alirocumab lowered LDL cholesterol by 35% over placebo in ODYSSEY HoFH, the largest ever randomized lipid-lowering trial in homozygous familial hypercholesterolemia.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Cardiology News Source Type: news
ABSTRACTSerum lipid abnormalities (dyslipidemias) are major risk factors for cardiovascular disease in type 2 diabetes. The features of diabetic dyslipidemia are elevated plasma concentrations of triglyceride (TG) ‐rich lipoproteins (TRLs), small dense low‐density lipoprotein cholesterol (sdLDL‐C) and decreased plasma high‐density lipoprotein cholesterol (HDL‐C) concentration
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: JDI UPDATES Source Type: research
As the COVID-19 outbreak worsens in the U.S., at-home test kits for the virus have been a source of both hope and controversy. Their appeal is clear: sick individuals could get a diagnosis from the comfort of home, without infecting others. But their downsides are real: the U.S. Food and Drug Administration (FDA) has cracked down on unauthorized at-home COVID-19 tests, updating its emergency use authorization guidelines to exclude at-home test kits and warning Americans that no such tests have received agency authorization. That means startups previously offering these products—such as Everlywell, Nurx and Carbon Hea...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
As yet there's no magic bullet that offers protection against coronavirus. And even though vitamin C supplements are selling in huge quantities, hard evidence on its effectiveness is lacking.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionsMore macrovascular and microvascular complications were found in Northern compared to Southern patients, and the largest difference also appeared in the younger age groups under 55, which may be meaningful to a screening and treatment strategy according to geographic differences.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Verotoxin, VT (aka Shiga toxin,Stx) is produced by enterohemorrhagic E. coli (EHEC) and is the key pathogenic factor in EHEC-induced hemolytic uremic syndrome (eHUS-hemolytic anemia/thrombocytopenia/glomerular infarct) which can follow gastrointestinal EHEC infection, particularly in children. This AB5 subunit toxin family bind target cell globotriaosyl ceramide (Gb3), a glycosphingolipid (GSL) (aka CD77, pk blood group antigen) of the globoseries of neutral GSLs, initiating lipid raft-dependent plasma membrane Gb3 clustering, membrane curvature, invagination, scission, endosomal trafficking, and retrograde traffic via the...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
This study aimed to investigate the vitamin D status, and analyze the relationship between vitamin D deficiency and metabolic risk factors in PCOS women in Shaanxi China.Methods: A cross-sectional study included 169 women diagnosed with PCOS and 114 control women without PCOS. The serum 25(OH)D and metabolic markers were measured. Vitamin D deficiency was defined as serum 25(OH)D concentration less than 20 ng/mL. The primary outcome was the difference in vitamin D status between the PCOS and control groups, the secondary outcomes were correlations between serum 25(OH)D concentration and metabolic risk factors in women with...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Nature Reviews Cardiology, Published online: 31 March 2020; doi:10.1038/s41569-020-0373-0The safety and durability of the LDL-cholesterol-lowering effects of inclisiran, a small interfering RNA that inhibits the synthesis of PCSK9 in the liver, have now been confirmed in three phase III clinical trials published in the New England Journal of Medicine.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research
AbstractLipocalin ‐2 (LCN2) is a secreted glycoprotein involved in several chronic inflammatory processes. Metabolic syndrome (MetS) and adult growth hormone deficiency (GHD) are known as chronic inflammatory conditions. The primary objective of this observational cross‐sectional study was to compare LCN2 plasmat ic levels in these clinical settings, whereas the secondary objective was to investigate any possible correlation between LCN2 and BMI and/or indexes of insulin sensitivity/resistance. Seventy‐four patients were divided as follows: Group A, MetS (18 patients, 13 females and 5 males, mean ±&thin...
Source: BioFactors - Category: Biochemistry Authors: Tags: Research Communication Source Type: research
This study aimed to determine the temporal profile of metabolic responses of the liver to cold exposure and changes of the hepatic NAD+/SIRT system. Eight ‐week‐old male C57BL/6 mice were individually housed in conventional cages under cold exposure (4°C) for up to five days. Cold exposure decreased the hepatic triglyceride level and cholesterol level in mice by 1.7‐ and 1.6‐fold, respectively. Lipogenic gene expression was persistently reduc ed, while gluconeogenic gene expression was transiently increased. Hepatic NAD+/SIRT metabolism was induced during the "cold remodeling" phase (days 1 ‐3) and ...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
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