Uvarialuridols A-C, three new polyoxygenated cyclohexenes from the twig and leave extracts of Uvaria lurida.

Uvarialuridols A-C, three new polyoxygenated cyclohexenes from the twig and leave extracts of Uvaria lurida.
Fitoterapia. 2019 Aug 26;:104340
Authors: Suthiphasilp V, Maneerat W, Andersen RJ, Patrick BO, Phukhatmuen P, Pyne SG, Laphookhieo S
Abstract
The first phytochemical investigation of Uvaria lurida resulted in the isolation and identification of three new polyoxygenated cyclohexenes, (+)-(1R,2S,3R,6S)-uvarialuridols A-C (1-3), together with 10 known compounds (4-13). All new structures were elucidated by spectroscopic methods and HRESIMS. The absolute configurations of compounds 1 and 5 were confirmed by X-ray diffraction analysis using Cu Kα radiation. The absolute configurations of compounds 2-4 were identified from comparisons of their specific rotations and ECD spectra with those of known compounds. Compound 11 showed α-glucosidase inhibitory activity with an IC50 value of 30 μM which was better than the standard control, acarbose (74 μM) whereas, compound 10 exhibited nitric oxide (NO) production inhibitory activity with an IC50 value of 37 μM.
PMID: 31465816 [PubMed - as supplied by publisher]

Source: Fitoterapia - August 25, 2019 Category: Biochemistry Authors: Suthiphasilp V, Maneerat W, Andersen RJ, Patrick BO, Phukhatmuen P, Pyne SG, Laphookhieo S Tags: Fitoterapia Source Type: research