Iron-Catalyzed Radical Methylation of Activated Alkenes with tert-Butanol as the Methyl Source

Synlett DOI: 10.1055/s-0039-1690193 A free-radical-initiated methylation/addition/cyclization of N-arylacrylamides and a methylation/addition/elimination of quinines have been developed in which t-BuOH is used as a methyl source. These reactions provide effective and selective methods for the synthesis of various methylated oxindoles and quinones in moderate to good yields. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - August 26, 2019 Category: Chemistry Authors: Xu, Zhengbao Jia, Rui Ma, Zhiwei Cao, Shouhao Shen, Liang Ji, Hongfang Tags: letter Source Type: research