1024 - epigenetic control of myeloid cell development by the transcription factor irf8

Differentiation of hematopoietic stem and progenitor cells to various types of blood cells is a process of establishing cell type-specific gene expression patterns. We have been investigating the mechanism of myeloid cell development from a viewpoint of gene expression control by transcription factors, particularly IRF8. In Irf8 –/– mice, mononuclear phagocyte progenitors are accumulated, and these progenitors do not efficiently differentiate into monocytes (Mos) or dendritic cells (DCs) but instead, give rise to a large number of neutrophils.

Source: Experimental Hematology - July 31, 2019 Category: Hematology Authors: Tomohiko Tamura Source Type: research