Targeting Degradation of the Transcription Factor C/EBP β Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

Dysregulation of the ubiquitin-editing enzyme A20 contributes to the development of several human inflammatory diseases. Liu et  al. demonstrate that suppression of A20 enzymatic activity in alveolar macrophages promotes lung fibrosis by reducing transcriptional factor C/EBPβ degradation and enhancing targeted gene expression, which directs the profibrotic phenotype of macrophages.

Source: Immunity - August 26, 2019 Category: Allergy & Immunology Authors: Shan-shan Liu, Xiao-xi Lv, Chang Liu, Jie Qi, Yun-xuan Li, Xu-peng Wei, Ke Li, Fang Hua, Bing Cui, Xiao-wei Zhang, Jiao-jiao Yu, Jin-mei Yu, Feng Wang, Shuang Shang, Chen-xi Zhao, Xue-ying Hou, Zhi-gang Yao, Ping-ping Li, Xia Li, Bo Huang, Zhuo-wei Hu Tags: Article Source Type: research