Low SATB1 expression promotes IL-5 and IL-9 expression in Sezary Syndrome

We read with interest the letter to the Editor by Gagat et al. on the ambiguous role of special AT-rich sequence-binding protein-1 (SATB1) expression in malignant tumors (Gagat et al., 2019). The authors make a strong point that miR-155/SATB1 axis contributes to apoptosis resistance not only in malignant T cells, but is also critical in regulating cell death in wide range of cell lines from hematologic malignancies to solid tumors. Among other findings, the authors report that low SATB1 expression is associated with resistance to apoptosis and poor responses to UV treatment in mycosis fungoides (MF).

Source: Journal of Investigative Dermatology - August 25, 2019 Category: Dermatology Authors: Alberto Herrera, Simon Fredholm, Anthony Cheng, Eleni P. Mimitou, Angelina Seffens, Michal Bar-Natan, Amy Sun, Joan Latkowski, Andreas Willerslew-Olsen, Terkild B. Buus, Maria Gluud, Thorbj ørn Krejsgaard, Sara Torres-Rusillo, Charlotte Menné Bonefeld, Tags: Letters to the Editor Source Type: research