Robust Design for Coalescent Model Inference

AbstractThe coalescent process describes how changes in the size or structure of a population influence the genealogical patterns of sequences sampled from that population. The estimation of (effective) population size changes from genealogies that are reconstructed from these sampled sequences is an important problem in many biological fields. Often, population size is characterized by a piecewise-constant function, with each piece serving as a population size parameter to be estimated. Estimation quality depends on both the statistical coalescent inference method employed, and on the experimental protocol, which controls variables such as the sampling of sequences through time and space, or the transformation of model parameters. While there is an extensive literature on coalescent inference methodology, there is comparatively little work on experimental design. The research that does exist is largely simulation-based, precluding the development of provable or general design theorems. We examine three key design problems: temporal sampling of sequences under the skyline demographic coalescent model, spatio-temporal sampling under the structured coalescent model, and time discretization for sequentially Markovian coalescent models. In all cases, we prove that 1) working in the logarithm of the parameters to be inferred (e.g., population size) and 2) distributing informative coalescent events uniformly among these log-parameters, is uniquely robust. “Robust” means that th...

Source: Systematic Biology - February 6, 2019 Category: Biology Source Type: research