Histone Acetyltransferase 1 Links Metabolism and Transcription to Cell-Cycle Progression

HAT1 is an essential gene in mammals that acetylates newly synthesized histone H4 and is involved in chromatin assembly and genome maintenance. In this issue of Molecular Cell, Gruber et  al. (2019) show that HAT1 binds to and stimulates H4 gene expression in a growth-factor- and glucose-dependent manner.

Source: Molecular Cell - August 21, 2019 Category: Cytology Authors: John M. Denu Tags: Preview Source Type: research