Aluminum phosphate vaccine adjuvant: Analysis of composition and size using off-line and in-line tools

ConclusionThis study demonstrated that in-line PAT can be used to monitor particle size and chemical composition for the various stages of adjuvant manufacturing from raw materials through intermediate to final adjuvant product stage. Similar approaches can be utilized to help assess lot-to-lot consistency during adjuvant manufacturing and vaccine product development. Moreover, the use of in-line PAT is highly conductive to advanced manufacturing strategies such as real-time product release testing and automated processes of the future.Graphical Abstract
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research