Clinical relevance for serum cold-inducible RNA-binding protein level in alopecia areata

Alopecia areata (AA), a chronic, relapsing hair-loss disorder, is considered to be a T-cell-mediated autoimmune disease. Cold-inducible RNA-binding protein (CIRP) belongs to the family of cold shock protein that responds to cold stress, which has been identified as a damage-associated molecular pattern (DAMP) molecule that triggers inflammatory responses. Recent studies have shown high-mobility group box 1 which is also one of the DAMP molecules is elevated in serum and scalp tissue of AA patients suggesting the relationship between DAMP and pathogenesis of AA.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research