Progressive alopecia, recalcitrant acne, and hirsutism as the presenting signs of a Leydig cell tumor of the ovary

Case Report: A 67-year-old woman with a history of rosacea presented with recalcitrant cystic acne. Additionally, the patient reported a 2-year history of gradual scalp hair loss and an increase in facial hair. There was no personal or family history of alopecia, hirsutism, or hyperandrogenism. Physical examination revealed excessive hair on her upper lip, chin, and lateral cheeks. She also had severe frontoparietal hair loss, thinning on the crown, and nodulocystic acne on her chin and cheeks. Laboratory tests showed markedly elevated levels of total testosterone (539 ng/dL), free testosterone (61.8 pg/mL) and DHEA-S (258 ug/dL).
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research