Rituximab-induced serum sickness with mucous membrane involvement

A 9-year-old female with a history of immune thrombocytopenic purpura on rituximab presented to the ED with 3 days of progressive erythroderma, fevers to 39.5 °C, and arthralgias. The illness initially began 8 days after her second rituximab dose with fever, chills and headache and evolved to right foot and knee pain. A patchy erythematous rash then developed on her right upper extremity and spread diffusely. On exam, she was ill appearing and had conjun ctival injection, erythema and cracking of the mucosal lips and a strawberry red tongue.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research