New, less-expensive inactivated polio vaccine non-inferior to conventional inactivated vaccine

Hu Y, Wang J, Zeng G, Chu K, Jiang D, Zhu F, et al. Immunogenicity and Safety of a Sabin Strain-Based Inactivated Polio Vaccine: A Phase 3 Clinical Trial. J Infect Dis 2019 pii: jiy736.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Current Best Evidence Source Type: research

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[ANGOP] Luanda -The second stage of polio vaccination campaign is kicking off this Friday in five provinces of Angola, the Health Ministry said on Thursday.
Source: AllAfrica News: Polio - Category: Infectious Diseases Source Type: news
This report updates previous reports on Pakistan's polio eradication activities, progress, and challenges (2,3). In 2018, Pakistan reported 12 WPV1 cases, a 50% increase from eight cases in 2017, and a 31% increase in the proportion of WPV1-positive sites under environmental surveillance (i.e., sampling of sewage to detect poliovirus). As of November 7, 2019, 80 WPV1 cases had been reported, compared with eight cases by the same time in 2018. An intensive schedule of supplementary immunization activities (SIAs)* implemented by community health workers in the core reservoirs (i.e., Karachi, Peshawar, and Quetta) where WPV1 ...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
This report presents data on cVDPV outbreaks detected during January 2018-June 2019 (as of September 30, 2019). Compared with January 2017-June 2018 (3), the number of reported cVDPV outbreaks more than tripled, from nine to 29; 25 (86%) of the outbreaks were caused by cVDPV2. The increase in the number of outbreaks in 2019 resulted from VDPV2 both inside and outside of mOPV2 response areas. GPEI is planning future use of a novel type 2 OPV, stabilized to decrease the likelihood of reversion to neurovirulence. However, all countries must maintain high population immunity to decrease the risk for cVDPV emergence. Cessation ...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Afghanistan and Pakistan are the only countries that continue to confirm ongoing wild poliovirus type 1 transmission.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report Polio (poliomyelitis) Polio Vaccination Population health Source Type: news
Since the launch of the Global Polio Eradication Initiative in 1988 and broad use of live, attenuated oral poliovirus vaccine, the number of wild poliovirus cases has declined>99.99%.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Diabetes Eye and Vision Health MMWR Morbidity & Mortality Weekly Report Outbreaks Polio (poliomyelitis) Polio Vaccination Population health Smoking Tobacco Use Vaccines Cigarette Smoking Source Type: news
A Nigerian father who used to chase health workers away from his home has a change of heart.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
We describe secular trends and socioeconomic disparities from 1982 to 2015, using data from four population-based birth cohorts carried out in the city of Pelotas. Full immunization coverage (FIC) was defined as having received four basic vaccines (one dose of BCG and measles, and three doses of polio and DTP) scheduled for the first year of life. Information on income was collected through standardized questionnaires, and the slope index of inequality (SII) was calculated to express the difference in percent points between the rich and poor extremes of the income distribution. Full immunization coverage was 80.9% (95% CI ...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
[ANGOP] Luanda -Staff of the Angolan Armed Forces (FAA) are expected to join the first stage of the vaccination campaign against polio, to be conducted on November 15-17, the Health minister, Silvia Lutukuta, said on Monday.
Source: AllAfrica News: Polio - Category: Infectious Diseases Source Type: news
Conclusion: The patient's psychiatric symptoms were most likely caused by anti-NMDA receptor encephalitis. Her polymorphic psychotic symptoms first occurred after she had received a Tdap-IPV booster vaccination. Although the vaccination cannot have caused the initial antibody formation since IgG serum antibodies were detected only 3 days after administration of the vaccine, the vaccine may have exerted immunomodulatory effects. MRI, EEG, and CSF findings were non-specific; however, FDG-PET identified brain involvement consistent with anti-NMDA receptor encephalitis. This case shows the importance of implementing a multimod...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSION: Non-inferiority of IPV-Al to IPV with respect to seroconversion was confirmed and a robust booster response was demonstrated. Both vaccines had a similar safety profile. ClinicalTrials.gov identifier: NCT03032419. PMID: 31703934 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
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