Validity of wearable actimeter computation of total energy expenditure during walking in post-stroke individuals

Publication date: Available online 10 August 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): M. Compagnat, S. Mandigout, C.S. Batcho, N. Vuillerme, J.Y. Salle, R. David, J.C. DavietAbstractBackgroundRecent studies reported that wearable sensor devices show low validity for assessing the amount of energy expenditure in individuals after stroke.ObjectiveWe aimed to evaluate the validity of energy expenditure calculation based on the product of energy cost and walked distance estimated by wearable devices in individuals after hemispheric stroke.MethodsWe recruited individuals with hemispheric stroke sequelae who were able to walk without human assistance. The participants wore a tri-axial accelerometer (Actigraph GT3x) and a pedometer (ONStep 400) on the unaffected hip in addition to a respiratory gas exchange analyzer (METAMAX 3B) during 6 min of walking at their self-selected walking speed and mode. The energy expenditure was calculated from the product of energy cost measured by the METAMAX 3B and the distance estimated by wearable devices. It was compared to the energy expenditure measured by the METAMAX 3B and the energy expenditure values recorded by the devices according to the manufacturer's algorithms. The validity was investigated by Bland-Altman analysis (mean bias [MB], root mean square error [RMSE], limits of agreement [95%LoA]), and Pearson correlation analysis (r).ResultsWe included 26 participants (mean [SD] age 64.6 [14.8] years). With ...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research

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ConclusionCollectively our data suggest that the bioactive chemical pool which is responsible for the therapeutic effects of EW can be extracted in petroleum ether, and fractionated to a relatively small multiple components. Such components include known anti-inflammatory chemicals, which may contribute to the possible microglia polarization in brain lesion during the recovery of ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionThe present method did not only preliminarily reveal the active substances and mechanism of NAC in treatment of IS from the perspective of network pharmacology, but show its potential application for research and development of other TCM prescriptions.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionUsing NMA, this study will offer new and informative evaluations of current TCPMs for ACI. The results will inform clinicians, provide optimal clinical treatment strategies, bridge the evidence gaps, and identify promising TCPMs for evaluation in future trials.The protocol has been registered on PROSPERO (International Prospective Register of Systematic Reviews) (CRD42018110307).
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 14 September 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): James J. Miller, Adam J. Kanack, Nancy M. DahmsAbstractBackgroundFabry disease is caused by α-galactosidase A deficiency. Substrates of this lysosomal enzyme accumulate, resulting in cellular dysfunction. Patients experience neuropathic pain, kidney failure, heart disease, and strokes.Scope of reviewThe clinical picture and molecular features of Fabry disease are described, along with updates on disease mechanisms, animal models, and therapies.Major conclusionsHow the accumulation of α-ga...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
PMID: 31519132 [PubMed - in process]
Source: Clinical Rehabilitation - Category: Rehabilitation Authors: Tags: Clin Rehabil Source Type: research
Photo credit Yoann Boyer Dear Carol: I was widowed young and had no children so when my mother had her first stroke in her 80s I moved her in with me. I recently remarried and my new husband’s fine with mom living with us since we have a large home, but problems are coming up and I feel torn. My husband wants us to travel some, and I want this, too. He’s good to Mom, but soon his resentment about us being tied down is bound to show in how he relates to her. Mom doesn’t want to go to a care facility because she says that they cost too much and she wants to leave her money to my brothers and me. I tell...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Publication date: Available online 14 September 2019Source: Molecular Genetics and MetabolismAuthor(s): Róisín M. Boggan, Albert Lim, Robert W. Taylor, Robert McFarland, Sarah J. PickettAbstractMitochondrial diseases, caused by mutations in either the nuclear or mitochondrial genomes (mtDNA), are the most common form of inherited neurometabolic disorders. They are remarkably heterogeneous, both in their clinical presentation and genetic etiology, presenting challenges for diagnosis, clinical management and elucidation of molecular mechanism. The multifaceted nature of these diseases, compounded by the unique ...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Source: Journal of Allied Health - Category: Universities & Medical Training Authors: Tags: International Perspectives. Source Type: research
ConclusionsFindings from this meta-analysis indicate that walking pace is inversely associated with the risk of stroke.Graphical abstract
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
CONCLUSION: Game-based chin-tuck against resistance exercise not only has a similar effect to head-lift exercise on swallowing function of patients with dysphagia, but is also a less strict and more enjoyable and interesting method. PMID: 31515567 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
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