A Positive Step toward Understanding Double-Negative Metastatic Prostate Cancer

Publication date: 12 August 2019Source: Cancer Cell, Volume 36, Issue 2Author(s): Michael M. ShenIn this issue of Cancer Cell, Su et al. demonstrate that epigenetic reprogramming by Polycomb Repressive Complex 1 (PRC1) promotes an inflammatory tumor microenvironment in a subtype of metastatic prostate cancer, and show that a PRC1 inhibitor can synergize with immune checkpoint inhibitors to suppress metastasis in mouse models.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research