Broad-Range Papillomavirus Transcriptome as a Biomarker of Papillomavirus-Associated Cervical High-Grade Cytology

Human papillomaviruses (HPVs) are responsible for>99% of cervical cancers. Molecular diagnostic tests based on the detection of viral DNA or RNA have low positive predictive values for the identification of cancer or precancerous lesions. Triage with the Papanicolaou test lacks sensitivity; and even when combined with molecular detection of high-risk HPV, this results in a significant number of unnecessary colposcopies. We have developed a broad-range detection test of HPV transcripts to take a snapshot of the transcriptome of 16 high-risk or putative high-risk HPVs in cervical lesions (HPVs 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 73, and 82).
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Regular article Source Type: research

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Publication date: Available online 12 August 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Philippe Pérot, Anne Biton, Jacques Marchetta, Anne-Gaelle Pourcelot, André Nazac, Henri Marret, Thomas Hébert, Delphine Chrétien, Marie-Christine Demazoin, Michaël Falguières, Laurence Arowas, Hélène Laude, Isabelle Heard, Marc EloitHuman papillomaviruses (HPVs) are responsible for>99% of cervical cancers. Molecular diagnostic tests based on the detection of viral DNA or RNA have low positive predictive values for the identification of cancer or precancerous lesio...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
CONCLUSION: The presence of small dysplastic cells displaying marked hyperchromasia,thickening of nuclear contour, and prominent nucleoli on Pap smear strongly suggest the presence of CIN in ASC-H cases. PMID: 31350977 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Authors: Song T, Seong SJ, Lee SK, Kim BR, Ju W, Kim KH, Nam K, Sim JC, Kim TJ Abstract The purpose of this study was to develop an ideal cervical cancer screening model to reduce false-negative errors in Korea where there is a high prevalence of cervical cancer. We conducted a cross-sectional study including 33,531 women who underwent routine cervical cancer screening in Korea. Colposcopic examinations were performed after abnormal results on their screening tests. Diagnostic capacities including sensitivity, specificity, and false-negative rate of each screening scenario were analysed at the CIN1 or worse (CIN1+)...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
(see:Startup uses phone, light and AI to detect cervical cancer)Israeli startup MobileODT has created the Eva System, which uses an Automated Visual Evaluation (AVE) algorithm that it says can detect cervical cancer by simply examining an image of the cervix (Courtesy) Israeli startup MobileODT has created the Eva System, which uses an Automated Visual Evaluation (AVE) algorithm that it says can detect cervical cancer by simply examining an image of the cervix (Courtesy) Israeli start-up MobileODT says it can detect cervical cancer more accurately and inexpensively than the standard colposcopy method used today, by creatin...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Source Type: blogs
Conclusions: Self-collection for HPV testing by women living in isolated communities is highly efficient and has potential for cost-effective screening by taking advantage of existing support networks, such as the local police service.Acta Cytologica
Source: Acta Cytologica - Category: Cytology Source Type: research
ConclusionCervicography and Pap co-testing had superior screening capacity and cost-effectiveness for detection of preinvasive cervical lesions than HPV and Pap co-testing and may be an effective and cost-saving screening strategy in clinical practice in country with a high prevalence of cervical cancer.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Conclusions: Onclarity is clinically validated for cotesting in NILM women. Genotyping actionably stratifies women at greater CIN3 or higher risk. PMID: 30649177 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research
Authors: Göktuğ Kadıoğlu B, Çınar Tanrıverdi E, Alay H, Uçar M Abstract Cervical cancer is a common female cancer that could be diagnosed early with screening methods. Almost all cases are caused by human papilloma virus (HPV) infection. Therefore, detecting the presence of HPV DNA is important for early diagnosis and treatment. Regular determination of screening tests enables early detection of patients with the risk of cervical cancer. For this purpose, since August 2014 a new screening program has been carried out by Early Diagnosis, Screening and Training of Cancer Centers (KETEM). The a...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
A recent article indicated that HPV testing is superior to the Pap smear for detecting precancerous lesions of the cervical epithelium (see:HPV test is better than Pap smear at detecting precancerous cervical changes). Has the Pap smear outlived its usefulness in cancer screening programs? Below is a key passage from the article:A new study found that the HPV test was better than the Pap smear in detecting precancerous changes that can lead to cervical cancer. A test for HPV detects precancerous changes of the cervix earlier and more accurately than the Pap smear....The randomized, controlled study...showed that the human ...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Cytopathology Healthcare Innovations Medical Research Public Health Surgical Pathology Source Type: blogs
Publication date: May–June 2018Source: Journal of the American Society of Cytopathology, Volume 7, Issue 3Author(s): Maren Y. Fuller, Roxanne R. Mody, Eric Luna, Donna Armylagos, Mary R. Schwartz, Dina R. Mody, Yimin GeIntroductionHigh-risk human papillomavirus (hrHPV) testing is important in cervical cancer screening and management algorithms. Roche (Pleasanton, Calif.) cobas hrHPV testing is commonly performed on both ThinPrep (TP) and SurePath (SP) samples, but performance of these platforms has not been fully investigated in the literature.Materials and MethodsRoche hrHPV testing was performed on 47,885 (TP = 18,...
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
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