Carbapenem-Resistant KPC- and TEM-Producing Escherichia coli ST131 Isolated from a Hospitalized Patient with Urinary Tract Infection: First Isolation in Molise Region, Central Italy, July 2018

Microbial Drug Resistance, Ahead of Print.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research

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Microcins are low-molecular-weight, ribosomally produced, highly stable, bacterial-inhibitory molecules involved in competitive, and amensalistic interactions between Enterobacteriaceae in the intestine. These interactions take place in a highly complex chemical landscape, the intestinal eco-active chemosphere, composed of chemical substances that positively or negatively influence bacterial growth, including those originated from nutrient uptake, and those produced by the action of the human or animal host and the intestinal microbiome. The contribution of bacteria results from their effect on the host generated molecules...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
AbstractPurposeUrinary tract infections (UTI) are one of the most common reasons for prescribing antibiotics in primary care. In Switzerland, the Swiss Center for Antibiotic Resistances (ANRESIS) provides resistance data by passive surveillance, which overestimates the true resistance rates. The aim of this study was to provide actual data of the antimicrobial resistance patterns in patients with UTI in Swiss primary care.MethodsFrom June 2017 to August 2018, we conducted a cross-sectional study in 163 practices in Switzerland. We determined the resistance patterns of uropathogens in patients with a diagnosis of a lower UT...
Source: Infection - Category: Infectious Diseases Source Type: research
This study identified E. coli with AR mechanisms to commonly used antimicrobials and carrying mobile genetic elements, which could transfer AR genes to other bacteria in the aquatic environment.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In this study, potential inhibitors against FimH adhesin of type I pili were screened computationally that yielded ten compounds. These were further validated in vitro against adhesion and biofilm formation. The compounds, 1-Amino-4-hydroxyanthraquinone (Disperse Red 15 or DR15) and 4-(4′-chloro-4-biphenylylsulfonylamino) benzoic acid (CB1) impaired adhesion and biofilm formation without inhibiting the planktonic growth. Also, both compounds inhibited cell assemblages like autoaggregation and swarming motility by unknown mechanisms. DR15 was further derivatized into N-(4-hydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
CONCLUSIONS: Empirical choice of antimicrobial agent for community-acquired non-complicated UTIs in women should be individualized on the basis of the patient's age, prevalence of resistance in the local community, and compliance history of the patient. PMID: 31580562 [PubMed - in process]
Source: Central European Journal of Public Health - Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research
Authors: Larramendy S, Gaultier A, Giffon S, Thibaut S, Caillon J, Moret L, Beaudeau F PMID: 31575447 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
In this study, we investigated the genetics behind mecillinam resistance which occurred in an extended ‐spectrum β‐lactamase‐producingEscherichia coli during pivmecillinam treatment of a patient. The genomic comparison of the two isolates points toward a mutational change of blaCTX ‐M‐15 into blaCTX‐M‐127 along with a serotype shift from rough to full‐length O25 as the mechanisms contributing to the change in mecillinam susceptibility. AbstractPivmecillinam (amdinocillin pivoxil) is the recommended first ‐choice antibiotic used to treat urinary tract infections (UTIs) in Denmark. The frequency of mut...
Source: MicrobiologyOpen - Category: Microbiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
A 63-year-old-woman presented to the emergency department with acute-onset, 8 out of 10, stabbing lower-abdominal pain associated with nausea and vomiting. The pain was constant and present in both lower quadrants. She denied diarrhea, constipation, hematemesis, and hematochezia/melena. She had presented to her family physician 5 days earlier with dysuria. At that time, urine dipstick was positive for nitrites and culture grew Escherichia coli (E.  coli), and she was prescribed a 7-day course of nitrofurantoin for a urinary tract infection (UTI).
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents ’ clinic Source Type: research
This study included 5201 pediatric patients with UTIs and found that urine with P. mirabilis or P. aeruginosa demonstrated the least acidic pH (mean pH = 6.72 and 6.62, respectively), whereas urine with E. coli or K. pneumoniae exhibited the most acidic pH (pH = 6.21 and 6.18). After stratifying the UTI samples by their pH range (
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
(CNN) — When multidrug-resistant pathogens kept reappearing on the skin of premature babies in a German hospital’s neonatal intensive care unit, investigators were confused. Tests for contamination in the incubators, as well as among healthcare workers who came into contact with the preemies, were all coming up negative, according to a report on the case published Friday by the American Society for Microbiology. But tests showed the babies were continually being reinfected with Klebsiella oxytoca, a bacteria notorious for hospital-acquired infections such as pneumonia, urinary tract infection, soft tissue infec...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Offbeat CNN Source Type: news
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