Dead-time correction for spectroscopic photon-counting pixel detectors
Modern photon-counting pixel detectors have enabled a revolution in applications at synchrotron light sources and beyond in the last decade. One of the limitations of the current detectors is their reduced counting linearity or even paralysis at high counting rates, due to dead-time which results in photon pile-up. Existing dead-time and pile-up models fail to reproduce the complexity of dead-time effects on photon-counting, resulting in empirical calibrations for particular detectors at best, imprecise linearization methods, or no linearization. This problem will increase in the future as many synchrotron light sources plan significant brilliance upgrades and free-electron lasers plan moving to a quasi-continuous operation mode. Presented here are the first models that use the actual behavior of the analog pre-amplifiers in spectroscopic photon-counting pixel detectors with constant current discharge (e.g. the Medipix and CPix families of detectors) to deduce more accurate analytical models and optimal linearization methods. In particular, for detectors with at least two counters per pixel, the need for calibration, or previous knowledge of the detector and beam parameters (dead-time, integration time, large sets of synchrotron filling patterns), is completely eliminated. This is summarized in several models of increasing complexity and accuracy. Finally, a general empirical approach is presented, applicable to any particular cases where the analytical approach is not suffic...
CLEVELAND - Two healthcare organizations are coming together to form a joint venture that will expand the boundaries of care through telehealth. Cleveland Clinic and American Well announced the joint venture named The Clinic, during the first day of the 2019 Medical Innovation Summit (MIS). Cleveland Clinic will offer up its expertise in virtual care and Boston-based American Well will contribute its digital health technology platform. The two companies are focused on leading the industry toward integrated, digital care delivery models that complement and are connected to traditional care settings. Executives from the orga...
CONCLUSIONS In a summary, by inhibiting the STAT3 activation, esculetin shows potential anticancer effects against the laryngeal cancer. PMID: 31630150 [PubMed - in process]
Is switching to this dual regimen an effective strategy for older HIV patients with toxicity concerns or comorbidities?HIV Medicine
Introduction:Prehospital pediatric endotracheal intubation has lower first-pass success rates compared to adult intubations and in general may not offer a survival benefit. Increasingly, emergency medical services (EMS) systems are deploying prehospital extraglottic airways (EGA) for primary pediatric airway management, yet little is known about their efficacy. We evaluated the impact of a pediatric prehospital airway management protocol change, inclusive of EGAs, on airway management and patient outcomes in children in cardiac arrest or respiratory failure.Methods: Using data from a large, metropolitan, fire-based EMS ser...
Industry players examined the intersection of sex, tech, health and pleasure at the Giant Health event in London last week.
This is the second partnership that Singapore-headquartered Doctor Anywhere has announced in Vietnam in a period of about two months.
CONCLUSIONS: Despite the slight increases in the 10-year observation period a stable trend cannot be assumed. However, this study might be useful as baseline for other studies on SDM implementation. PMID: 31629688 [PubMed - as supplied by publisher]
[Daily Trust] The Federal Government has pledged $12 million to the Global Fund to tackle HIV, tuberculosis and malaria.
CONCLUSION: Ultrastructural changes in rat liver tissue in conditions of obstructive jaundice may be reversible after restoration of drainage. On the other hand, ultrastructural changes in renal tissue in cases of prolonged jaundice are irreversible even if the internal drainage is restored. KEY WORDS: Bile Duct, Liver, Kidney, Obstructive Jaundice. PMID: 31630139 [PubMed - as supplied by publisher]
Authors: Pierret T, Briault A, Reymond E, Benet J, Arbib F, Pison C PMID: 31629604 [PubMed - as supplied by publisher]
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