Computational Analysis of Protein-Protein Interactions in Motile T-Cells.
Computational Analysis of Protein-Protein Interactions in Motile T-Cells.
Methods Mol Biol. 2019;1930:149-156
Authors: Kumar S, Fazil MHUT, Ahmad K, Tripathy M, Rajapakse JC, Verma NK
Abstract
Analysis of protein-protein interactions is important for better understanding of molecular mechanisms involved in immune regulation and has potential for elaborating avenues for drug discovery targeting T-cell motility. Currently, only a small fraction of protein-protein interactions have been characterized in T-lymphocytes although there are several detection methods available. In this regard, computational approaches garner importance, with the continued explosion of genomic and proteomic data, for handling protein modeling and protein-protein interactions in large scale. Here, we describe a computational method to identify protein-protein interactions based on in silico protein design.
PMID: 30610609 [PubMed - indexed for MEDLINE]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Kumar S, Fazil MHUT, Ahmad K, Tripathy M, Rajapakse JC, Verma NK Tags: Methods Mol Biol Source Type: research
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