Antenatal sildenafil treatment improves neonatal pulmonary hemodynamics and gas exchange in lambs with diaphragmatic hernia.

CONCLUSIONS: Sustained maternal antenatal sildenafil infusion reduced pulmonary arterial pressure and increased pulmonary blood flow in DH lambs for the first 120 min after birth. These findings of improved pulmonary vascular function are consistent with improved pulmonary vascular structure seen in two previous animal models. The data support the rationale for a clinical trial with antenatal sildenafil to reduce the risk of neonatal pulmonary hypertension in infants with CDH. This article is protected by copyright. All rights reserved.
PMID: 31364206 [PubMed - as supplied by publisher]

Source: The Ultrasound Review of Obstetrics and Gynecology - July 30, 2019 Category: Radiology Authors: Kashyap AJ, DeKoninck PLJ, Rodgers KA, Thio M, McGillick EV, Amberg BJ, Skinner SM, Moxham AM, Russo FM, Deprest JA, Hooper SB, Crossley KJ, Hodges RJ Tags: Ultrasound Obstet Gynecol Source Type: research