The N6-Methyladenosine (m6A)-Forming Enzyme METTL3 Facilitates M1 Macrophage Polarization through the Methylation of STAT1 mRNA.

In conclusion, METTL3 drives M1 macrophage polarization by directly methylating STAT1 mRNA, potentially serving as an anti-inflammatory target.
PMID: 31365297 [PubMed - as supplied by publisher]

Source: Am J Physiol Cell Ph... - July 30, 2019 Category: Cytology Authors: Liu Y, Liu Z, Tang H, Shen Y, Gong Z, Xie N, Zhang X, Wang W, Kong W, Zhou Y, Fu Y Tags: Am J Physiol Cell Physiol Source Type: research