[Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K/AKT/mTOR pathway].

CONCLUSIONS: We demonstrate that matrine inhibits the proliferation and induces autophagy and apoptosis of A549 cells by deactivating AKT pathway, suggesting the potential of matrine as an anti-cancer agent for lung cancer.
PMID: 31340906 [PubMed - in process]

Source: Journal of Southern Medical University - July 27, 2019 Category: Universities & Medical Training Authors: Hao Y, Yin H, Zhu C, Li F, Zhang Y, Li Y, Wang X, Li D Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research