Circulating endothelial and progenitor cells in age-related macular degeneration.
CONCLUSION: We reported higher levels of circulating endothelial cells in age-related macular degeneration patients in comparison with the control group, thereby supporting the hypothesis of an involvement of endothelial dysregulation in the age-related macular degeneration and a reduction of the endothelial progenitor cell level in neovascular age-related macular degeneration patients after three intravitreal injections of ranibizumab. PMID: 31328962 [PubMed - as supplied by publisher]
Conclusions: In fetal RPE cells, Gremlin-1 induces EMT and inhibits redifferentiation by promoting the TGF-β pathway and inhibiting the BMP pathway. GREM1 silencing alleviates EMT and increases the redifferentiation of cells by relieving the blockade of the BMP pathway. However, GREM1 silencing has no effects on the TGF-β pathway. Thus, Gremlin-1 may serve as a novel target to treat proliferative vitreoretinopathy (PVR) and inhibit subretinal fibrosis, which is a risk factor for influencing the therapeutic effects of anti-vascular endothelial growth factor (anti-VEGF) on neovascular age-related macular degenerati...
Conclusion. One dose + PRN showed noninferior visual gains than 3 loading doses + PRN regimen using ranibizumab in Chinese nvAMD and PCV patients. Number of injections in the PRN group was similar as that in the LD group but remained a potential risk of vision instability during one-year follow-up using OCT-guided retreatment criteria. This trial is registered with NCT02810808. PMID: 31687203 [PubMed]
Conclusions: FCE are relatively frequently encountered morphologic features of elderly patients with ARMD, high myopia, and ARCA, and have a distinct clinical and imaging morphology which differs from classically described chorioretinal folds. The lesions may commonly be mistaken for pigment epithelial detachments on ophthalmoscopy, may be associated with CNV in fellow eyes, and have a characteristic SD-OCT appearance. PMID: 31687198 [PubMed]
To determine the association of age-related macular degeneration (AMD) with Alzheimer ’s disease (AD) and Parkinson’s disease (PD).
Conclusion: This study illuminates the low utilization of eye care among socioeconomically disadvantaged older adults residing in SSH, especially among those with vision impairment and eye disease. Vision-related health care is important in maintaining both physical and mental health in older adults. PMID: 31694391 [PubMed - as supplied by publisher]
CONCLUSIONS: PPS exposure was associated with a new diagnosis of macular disease at the 7-year follow-up in a large national cohort. PMID: 31694837 [PubMed - as supplied by publisher]
Condition: Age-related Macular Degeneration Intervention: Drug: BAT5906 injection Sponsor: Bio-Thera Solutions Recruiting
We read the article by Liu and associates1; however, we believe that some discussion is required. The authors present the results of conbercept (Lumitin, Chengdu Kanghong Biotech Co., PR of China) treatment of neovascular age-related macular degeneration (AMD).
This article is intended to give an overview of possible applications. PMID: 31671463 [PubMed - as supplied by publisher]
This study compares 2 methods of macular function evaluation: the microperimetric examination (mean central retinal sensitivity and fixation stability) and the distance best-corrected visual acuity (BCVA) examination, which is the most frequently used method of assessing macular function in patients with newly diagnosed wet age-related macular degeneration (AMD) who have been treated with anti-vascular endothelial growth factor (VEGF) drug (aflibercept). Prospective analysis was conducted on 44 eyes of 44 patients treated with intravitreal injection of anti-VEGF (aflibercept) because of newly diagnosed neovascular AMD. Ac...