Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.

Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.
Bioorg Med Chem. 2019 Jul 15;:
Authors: Cheng Z, Valença WO, Dias GG, Scott J, Barth ND, de Moliner F, Souza GBP, Mellanby RJ, Vendrell M, da Silva Júnior EN
Abstract
Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.
PMID: 31327676 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry - July 14, 2019 Category: Chemistry Authors: Cheng Z, Valença WO, Dias GG, Scott J, Barth ND, de Moliner F, Souza GBP, Mellanby RJ, Vendrell M, da Silva Júnior EN Tags: Bioorg Med Chem Source Type: research