Ex vivo human models of hidradenitis suppurativa/acne inversa for laboratory research and drug screening.
Ex vivo human models of hidradenitis suppurativa/acne inversa for laboratory research and drug screening. Br J Dermatol. 2019 Jul 18;: Authors: Zouboulis CC PMID: 31321767 [PubMed - as supplied by publisher]
The increasing prevalence of Metabolic syndrome (MetS) is a worldwide health problem, and the association between MetS and skin diseases has recently attracted growing attention. In this review, we summarize the associations between MetS and skin diseases, such as psoriasis, acne vulgaris, hidradenitis suppurativa, androgenetic alopecia, acanthosis nigricans, and atopic dermatitis. To discuss the potential common mechanisms underlying MetS and skin diseases, we focus on insulin signaling and insulin resistance, as well as chronic inflammation including adipokines and proinflammatory cytokines related to molecular mechanism...
Conclusions and implicationsSome preliminary evidence supports the use of zinc in the treatment of acne vulgaris and hidradenitis suppurativa; however, more research is needed with similar methodologies and larger sample sizes in these diseases. Further, zinc may be of some benefit in the treatment plan for atopic dermatitis and diaper dermatitis; however, additional studies should be conducted to further evaluate these potentially positive associations. To date, no evidence is available to suggest that zinc may be of benefit in rosacea and psoriasis; however, limited data are available evaluating the use of zinc in these conditions.
DISCUSSION: Dermatological conditions that require paraclinical assistance for diagnosis, hands-on examination, or treatment with either biologics or surgery will all result in high CPP. However, teledermatology still has a place in the treatment of high-CPP dermatoses in rural areas because there is no other alternative. For non-rural areas, CPP can be used as a way to identify those dermatoses that are not advantageous to treat using telemedicine, but instead best benefit from standard face-to-face consultation. PMID: 31545386 [PubMed - in process]
Conclusions: Our data suggest that for HS patients, having a history of pilonidal cyst is associated with a beneficial response to isotretinoin. PMID: 31535587 [PubMed - as supplied by publisher]
Hidradenitis suppurativa (HS), also known as acne inversa, is an incapacitating skin disorder of unknown etiology manifested as abscess-like nodules and boils resulting in fistulas and tissue scarring as it progresses. Given that neutrophils are the predominant leukocyte infiltrate in HS lesions, the role of neutrophil extracellular traps (NETs) in the induction of local and systemic immune dysregulation in this disease was examined. Immunofluorescence microscopy was performed in HS lesions and detected the prominent presence of NETs. NET complexes correlated with disease severity, as measured by Hurley staging. Neutrophil...
A more reliable classification of skin inflammation and severity of active disease results by ultrasound sonography and the new HS classification system IHS4. However, an objective assessment of skin inflammation in a continuous mode is still the ultimate goal. Long-wave Medical Infrared Thermography (MIT) may offer a blood flow and temperature differential assessment in inflammatory conditions. This project was designed to evaluate the application of MIT in HS. Standardised photography of the areas involved or been candidate for HS involvement and MIT pictures of 18 patients [11 female, 7 male, median age 38.75 years (95%...
Hidradenitis suppurativa/acne inversa (HS) is a chronic, recurrent skin disease of the hair follicle. It manifests with painful, deeply localized, inflammatory skin lesions that occur in apocrine gland-rich areas of the skin, most commonly in the axillae and the inguinal and anogenital regions (Dessauer definition). The central pathogenic event in HS is believed to be the occlusion of the hair follicle leading to a perifollicular lymphohistiocytic inflammation. The purpose of this work was to develop a human HS model which could help to understand the pathophysiology of HS and to determine the action of therapeutic candidates.
In this study we investigated the expression and localization of the transglutaminase inhibitory proteins (SERPINB3/B4) and the antimicrobial proteins (S100A7-A9) in HS. Comparative analysis of gene expressi on in the lesional vs healthy appearing skin from microarray data of 8 affected patients and 4 healthy individuals showed 705 statistically significant upregulated genes and 482 downregulated (fold change>2, p
Acne inversa, also known as hidradenitis suppurativa (HS), is a neglected, prevalent, chronic, stigmatizing, and debilitating inflammatory skin disease. HS patients suffer from deep, painful, recurrent abscesses that drain malodorous fluid and lead to disfiguring scars that can limit mobility of the arms and legs. People with African ancestry have a more than two-fold increased risk of HS. A lack of effective therapies and limited knowledge about HS pathogenesis contribute to unmet needs. Unlike other common inflammatory skin diseases, there never has been a genome-wide association study (GWAS) conducted for HS.
This article is protected by copyright. All rights reserved. PMID: 31448409 [PubMed - as supplied by publisher]