The use of reaction time distributions to study attention in male rats: the effects of atomoxetine and guanfacine

ConclusionsIT devmode is a measure of distribution skew thought to reflect lapses of attention. The effects of ATX  on IT devmode suggest that increased synaptic NE reduces attentional lapses. These findings are consistent with human reports of reduced RTV after ATX administration. The same pattern of results with guanfacine suggests that the effects of increased NE are due in part to binding at α-2 noradrene rgic receptors.

Source: Psychopharmacology - July 17, 2019 Category: Psychiatry Source Type: research