Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST

Malignant peripheral nerve sheath tumor (MPNST) is a malignant tumor arising either from a peripheral nerve de novo, a preexisting benign nerve sheath tumor (usually neurofibroma), or in a patient with neurofibromatosis type 1 (NF1). The diagnosis of sporadic MPNST is based on the constellation of light microscopic, immunohistochemical and ultrastructural features suggesting Schwann cell differentiation (WHO 2013 edition page 187) [1]. Approximately 10% of MPNSTs develop as a consequence of prior radiation therapy [2 –5].

Source: Radiotherapy and Oncology - May 8, 2019 Category: Radiology Authors: Ruoyu Miao, Haotong Wang, Alex Jacobson, Anna P. Lietz, Edwin Choy, Kevin A. Raskin, Joseph H. Schwab, Vikram Deshpande, G. Petur Nielsen, Thomas F. DeLaney, Gregory M. Cote, Francis J. Hornicek, Yen-Lin E. Chen Tags: Original Article Source Type: research