Rational redox tuning of transition metal sites: learning from superoxide reductase.

Rational redox tuning of transition metal sites: learning from superoxide reductase. Chem Commun (Camb). 2019 Jul 15;: Authors: Horch M Abstract Using superoxide reductase as a model system, a computational approach reveals how histidine tautomerism tunes the redox properties of metalloenzymes to enable their catalytic function. Inspired by these experimentally inaccessible insights, non-canonical histidine congeners are introduced as new versatile tools for the rational engineering of biological transition metal sites. PMID: 31304493 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research