Rational redox tuning of transition metal sites: learning from superoxide reductase.
Rational redox tuning of transition metal sites: learning from superoxide reductase.
Chem Commun (Camb). 2019 Jul 15;:
Authors: Horch M
Abstract
Using superoxide reductase as a model system, a computational approach reveals how histidine tautomerism tunes the redox properties of metalloenzymes to enable their catalytic function. Inspired by these experimentally inaccessible insights, non-canonical histidine congeners are introduced as new versatile tools for the rational engineering of biological transition metal sites.
PMID: 31304493 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Horch M Tags: Chem Commun (Camb) Source Type: research