Medical News Today: How can rheumatoid arthritis affect the jaw?
Rheumatoid arthritis (RA) can affect the jaw joint, causing tenderness and swelling. In this article, we look at the symptoms and treatments for RA in the jaw.
This study establishes adjuvant-induced arthritis (AIA) mouse models and explores the anti-inflammatory efficacy of QAW in AIA mice. To enhance the targeting, responsiveness, and efficacy of QAW to inflammation, QAW (Q) is modified with a cell penetrating peptide (T), a matrix metalloproteases-2/9 (MMP-2/9) digestive peptide (M), and an inflammation targeting peptide-RGD (R). The designed RMTQ demonstrates enhanced delivery to cytoplasm, higher reduction of pro-inflammatory factors, and better efficacy than QAW. The anti-inflammatory efficacy of RMTQ is similar to that of DEX in this study whereas RMTQ treatment shows a hi...
Authors: Wang P, Mao YM, Liu LN, Zhao CN, Li XM, Pan HF Abstract A growing body of data suggests that semaphorins are involved in both normal and pathological immune responses, as well as autoimmune pathologies. To investigate the plasma semaphorin 3A (Sema3A) and semaphorin 7A (Sema7A) levels in systemic lupus erythematosus (SLE) patients and their correlation with clinical manifestations and laboratory indexes, a two-step method was applied. First, 80 SLE patients and 80 healthy controls were recruited for comparing serum Sema3A and Sema7A concentrations. Second, 40 rheumatoid arthritis (RA) patients and 40 sj&ou...
In conclusion, osteoporosis is prevalent among RA patients, as a part of a complex transformation of body mass composition, involving BMI and fat mass. The novel QUS scanning technique was able to replicate the results of the established DXA measurement of BMD and is potentially suitable for screening wide populations for osteoporosis. PMID: 31410123 [PubMed]
Find out how the safety profile for abatacept compared with that of other DMARDs for rheumatoid arthritis.Arthritis Research &Therapy
ConclusionReported cases of PTRCT and its surgical repair have both increased substantially over time. Approximately 11.70% of patients with PTRCT undergo either open or arthroscopic procedure as a means of surgical repair. With the growing popularity of arthroscopic procedures for rotator cuff repair, further investigation should be performed to analyze trends and risk factors for PTRCT, a seemingly underrepresented orthopedic condition.
Conclusion. There was no difference in TBL, intraoperative bleeding, and operation time, but HBL were higher in RA patients particularly in long-segmental operation. Steinbroker classification, DMARDs, the change of Hb, and allogeneic blood transfusion were independent risk factors for HBL in RA patients. Level of Evidence: 3
Condition: Rheumatoid Arthritis Interventions: Drug: SKI-O-703; Drug: Placebo Sponsor: Oscotec Inc. Recruiting
CONCLUSION: IL-34 may indirectly contribute to angiogenesis by promoting the production of VEGF and HIF-1α and participate in the pathogenesis of RA. PMID: 31401905 [PubMed - as supplied by publisher]
Conditions: Rheumatoid Arthritis; Synovial Disorder; Arthrosis Intervention: Procedure: Joint puncture Sponsor: University Hospital, Bordeaux Completed
Conditions: Cardiovascular Diseases; Arthritis, Rheumatoid Interventions: Drug: Atorvastatin; Drug: Colchicine Sponsor: Hospital Central " Dr. Ignacio Morones Prieto " Completed