Cervical Cancer Identification with Synthetic Minority Oversampling Technique and PCA Analysis using Random Forest Classifier

AbstractCervical cancer is the fourth most communal malignant disease amongst women worldwide. In maximum circumstances, cervical cancer indications are not perceptible at its initial stages. There are a proportion of features that intensify the threat of emerging cervical cancer like human papilloma virus, sexual transmitted diseases, and smoking. Ascertaining those features and constructing a classification model to categorize, if the cases are cervical cancer or not is an existing challenging research. This learning intentions at using cervical cancer risk features to build classification model using Random Forest (RF) classification technique with the synthetic minority oversampling technique (SMOTE) and two feature reduction techniques recursive feature elimination and principle component analysis (PCA). Utmost medical data sets are frequently imbalanced since the number of patients is considerably fewer than the number of non-patients. For the imbalance of the used data set, SMOTE is cast-off to solve this problem. The data set comprises of 32 risk factors and four objective variables: Hinselmann, Schiller, Cytology and Biopsy. Accuracy, Sensitivity, Specificity, PPA and NPA of the four variables remains accurate after SMOTE when compared with values obtained before SMOTE. An RSOnto ontology has been created to visualize the progress in classification performance.
Source: Journal of Medical Systems - Category: Information Technology Source Type: research

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ConclusionsResidual disease may be inconspicuous or absent on cytology, colposcopy and/or histology. Management taking account of risk of recurrence (age, CIN3 depth, incomplete initial excision) could avoid some post-treatment cancers.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
For its first few years on the market, the human papillomavirus (HPV) vaccine was approved only for young girls. Over time, the U.S. Food and Drug Administration (FDA) has broadened its approval to include boys, as well as adults up to age 45—allowing more people to get the cancer-preventing vaccine, but also breeding confusion about who should get vaccinated and when. On Thursday, the U.S. Centers for Disease Control and Prevention (CDC) released new recommendations, based on guidance from the Advisory Committee on Immunization Practices, that should clear up some of that confusion. The CDC reaffirmed that its prior...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime public health Source Type: news
British Journal of Cancer, Published online: 14 August 2019; doi:10.1038/s41416-019-0547-x16/18 genotyping in triage of persistent human papillomavirus infections with negative cytology in the English cervical screening pilot
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Barbara C Snoek, Iris Babion, Danijela Koppers-Lalic, Dirk M Pegtel, Renske DM SteenbergenHigh-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are small non-coding RNAs that exist as multiple length and sequence variants, termed isomiRs. Efficient processing of miRNAs and generati...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Roche has expanded the Global Access Program, originally established to increase availability of HIV diagnostics in underserved countries, to include diagnostic tests for tuberculosis, hepatitis, and human papillomavirus (HPV). Increased access to reliable diagnostics will allow early, possibly life-saving, detection and decrease the spread of these diseases. Roche launched the program in 2014 and began offering the added tests in July. The molecular diagnostics available include tests for determination of HIV-1 viral load, early diagnosis of HIV-1 and -2 in young infants, Mycobacterium tuberculosis (MTB) and rifampin/ison...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
Publication date: Available online 6 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Fernanda Costa Brandão Berti, Amanda Salviano-Silva, Helen Cristina Beckert, Karen Brajão de Oliveira, Gabriel Adelman Cipolla, Danielle MalheirosAbstractDespite Human Papillomavirus (HPV) essential role in cervical carcinogenesis, other factors are required for cancer establishment, like miRNAs. Such molecules present a complex biogenesis, being diversely distributed across tissues and biological fluids, as cell-free miRNAs or miRNAs present in extracellular vesicles (EV). After HPV infec...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research
To be effective, population-based cervical cancer prevention programs must be tailored to meet the needs of the target population. One important factor in cervical cancer screening may include male involvement...
Source: BMC Women's Health - Category: OBGYN Authors: Tags: Research article Source Type: research
Abstract The conventional prophylactic vaccines for human papillomavirus (HPV) efficiently prevent infection with high-risk HPV types, but they do not promote therapeutic effects against cervical cancer. Previously, we developed HPV16 E7-expressing Lactobacillus casei (L. casei-E7) as a therapeutic vaccine candidate for cervical cancer, which induces antitumor therapeutic effects in a TC-1 murine cancer model. To improve the therapeutic effect of L. casei-E7, we performed co-treatment with poly-gamma-glutamic acid (γ-PGA), a safe and edible biomaterial naturally secreted by Bacillus subtilis. We investigated...
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research
Contributors : Ayslan C Brant ; Miguel M MoreiraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Human papillomavirus type 16 ; Human papillomavirus type 18Human papillomavirus (HPV) genome integration into the host genome, blocking E2 expression and leading to overexpression of E6 and E7 viral oncogenes, is considered a major step in cervical cancer development. In high-risk HPVs, E6 and E7 oncogenes are expressed as a bicistronic pre-mRNA, with alternative splicing producing the ultimate mRNAs required for E6 and E7 translation. Given the number of alternative donor and acceptor s...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Human papillomavirus type 16 Human papillomavirus type 18 Source Type: research
irc; Abstract Cervical cancer is the fourth most common cancer among women worldwide and its development is mainly associated with human papillomavirus infection, a highly sexually transmissible virus. The expression of E6 and E7 viral oncoproteins deregulates cell repairing mechanisms through impairment of tumor suppressor protein functions, such as p53 or retinoblastoma protein. Although the implementation of new preventive vaccines has decreased the infection rate and cervical cancer progression, there are still many women who are affected by this pathology. Nowadays, the main treatment often requires the use o...
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Tags: Drug Discov Today Source Type: research
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